Neuroendocrine Tumors

Results of the TELEPRO-II study showed that telotristat ethyl (TE) treatment resulted in significant, clinically relevant improvements across carcinoid syndrome (CS) symptoms in a real-world setting.
Findings of a retrospective analysis suggest that patients with well-differentiated metastatic/unresectable grade 3 gastroenteropancreatic neuroendocrine tumors (GEP-NETs) may derive modest progression-free survival (PFS) benefit with somatostatin analog (SSA) monotherapy.
Findings of a comparative real-world analysis of long-acting somatostatin analogs (SSAs) indicate that lanreotide was associated with lower injection burden, use of rescue medications, and cost.
Results of the randomized, open-label phase 2 Australasian Gastrointestinal Trials Group CONTROL NET study indicate that capecitabine/temozolomide (CAPTEM) plus 177Lu-octreotate peptide receptor radionuclide therapy (PPRT) combination treatment was active and well-tolerated compared with CAPTEM or PPRT alone in patients with pancreatic neuroendocrine tumors (pNETs) and updated midgut neuroendocrine tumors (mNETs).
Real-world data from a retrospective analysis of octreotide long-acting release (LAR) dosing patterns on treatment persistence in patients with symptomatic metastatic neuroendocrine tumors (NETs) indicate that physician experience and treatment at tertiary centers has a significant impact on dose selection and treatment persistence.
Findings of a comparative retrospective analysis indicate that first-line octreotide long-acting release (LAR) and lanreotide treatment was associated with similar progression-free survival (PFS) and biochemical response in patients with metastatic, well-differentiated metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Results of the CLARINET FORTE trial showed that lanreotide autogel (LAN) 120 mg at escalating dosing frequency (every 14 days) was associated with promising progression-free survival (PFS) benefit and no new safety issues in patients with progressive pancreatic or midgut neuroendocrine tumors (NETs).
Results of the prospective phase 2 ATLANT study indicate that lanreotide autogel (LAN) plus temozolomide (TMZ) combination therapy was efficacious and well-tolerated in patients with progressive thoracic neuroendocrine tumors (NETs).
Preliminary results of an ongoing dose-escalation and expansion phase 1 (Duet 1; NCT03411915) trial indicate that the anti–somatostatin receptor type 2 (SSTR2) × anti-CD3 bispecific antibody XmAb18087 was well-tolerated and accompanied by sustained T-cell activation in patients with advanced neuroendocrine tumors (NETs).
A retrospective analysis of a large database of grade 3 gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) identified clinically relevant prognostic factors that could potentially inform clinical decisions in this setting.
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