Clinical Research
Palbociclib is the first-in-class cyclin-dependent kinase 4/6 inhibitor approved in the United States in combination with an aromatase inhibitor (AI) or fulvestrant for treating patients with hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2–) advanced or metastatic breast cancer (mBC) as initial or later-line endocrine therapy. More than 80,000 patients have been treated in the United States with palbociclib since its approval in February 2015, but data on real-world palbociclib utilization are limited.
Edythe M. Greenberg, PhD, RN, FNP-BC, Jillian Settlemire, RN, Sandra Dai, PhD, MS, James P. Dean, MD, PhD, Tony Lin, PharmD, Steven Coutre, MD, Jan Berger, MD, PhD
Ibrutinib is a first-in-class, once-daily inhibitor of BTK approved in the United States for treatment of CLL/SLL. RESONATE-2 is a phase 3 study comparing first-line ibrutinib versus chlorambucil in patients with CLL/SLL. Primary results (median follow-up, 18.4 months) demonstrated ibrutinib reduced risk of progressive disease (PD) or death by 84% (Burger, 2015).
The co-chairs of the AONN+ Clinical Trials Committee discuss the roles of navigators and researchers in clinical trials, barriers to clinical trials that navigators can mitigate, and helpful tips and talking points to consider when talking about clinical trials with patients.
The combination of the mammalian target of rapamycin (mTOR) inhibitor, everolimus, and the aromatase inhibitor, exemestane, is approved for use in postmenopausal women with HR+, HER2– ABC after failure on letrozole or anastrozole treatment.
This study describes the nurse perspective on the importance of biomarker testing for patients with metastatic non–small cell lung cancer (NSCLC) and identifies best practices and process gaps.
Endocrine therapy is recommended for patients with hormone receptor–positive (HR+) advanced and metastatic breast cancer without visceral crisis (symptomatic visceral disease).
Of the 1.6 million individuals annually diagnosed with cancer, 522,166 received chemoradation, with 234,975 developing toxic mucositis and 20% dying within 5 years due largely to mucositis-mediated unplanned treatment breaks.
Endometrial and ovarian cancers are the sixth and seventh most common cancers in women worldwide.
Symptoms that patients with cancer experience, either due to their illness or as a result of cancer treatment, are known to diminish their health-related quality of life.
Significantly improved outcomes with D+T vs BRAF inhibitor (BRAFi) monotherapy have been demonstrated in phase 3 BRAF V600E/K–mutant melanoma trials (COMBI-d [NCT01584648]; COMBI-v [NCT01597908]), supporting use of D+T as a treatment for this disease.
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